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Customer : Big Pharmaceutical Company
Process : 7- Stage chiral compound with one column chromatography
Deliverables :
  • Find a new scalable route
  • Delivery of 1 Kg with chiral purity NLT 98% ee
  •  
    Team : 3 Process Chemists & 1 Analytical Chemist
    Work Done :
  • New routes identified
  • One route (4 steps) taken up for development - avoids column chromatography
  • Chiral induction using Evans asymmetric strategy
  • Successfully completed feasibility & optimization
  • Chiral auxiliary recovery
  •  
    Result :
  • Enhanced chiral purity > 99 % ee
  • Fewer steps & recovery of chiral auxiliary made the process economical
  • Delivered 1 Kg within timelines – 4 months
  •  
    Customer : Big Pharmaceutical Company
    Process : No technical package available.
    Final compound known to be unstable - Liquid
    Deliverables :
  • Scalable process
  • Delivery of 10 Kgs
  •  
    Team : 4 Process Chemists, 1 Analytical Chemist & KL manufacturing
    Work Done :
  • Two new routes identified
  • Both taken up for laboratory feasibility; 5 Step process is finalized
  • Resolved issue of regio-isomer and stability issue by making salt
  • Process taken for scale up
  •  
    Result :
  • Robust and scalable process
  • Delivered 10 Kgs within timelines – 5 months
  •  
    Customer : Big Pharmaceutical Company
    Process : Technical package available
    Deliverables :
  • Delivery of 200 Kgs meeting specifications
  • Team : 3 Process Chemists, 1 Analytical Chemist & manufacturing
    Work Done :
  • 5 chemical conversions and 2 isolated stages from commercially available raw materials
  • 7% overall yield improvement
  • Technology transferred to plant
  •  
    Result :
  • On Time In Full Delivery - 3 months
  • Three reload campaigns – 200 Kgs & 2 X 950 Kgs
  • Developed two new vendors for critical raw material
  •  
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